Walee Chamulitrat (Ph.D., Associate Prof.)

Page last updated on June 2017

List of Content

Some More Recent Papers
Free Radicals
Some Pictures: Work Related
Some Pictures: Family Related
My Orchids
Two Home Towns: Udon and Bangkok
Some Links

Some Recent Papers 1

Seessle, J., Liebisch, G., Staffer, S., Tuma-Kellner, S., Merle, U., Herrmann, T., Chamulitrat, W. (2024), Enterocyte-specific FATP4 deficiency elevates blood lipids via a shift from polar to neutral lipids in distal intestine, Am J Physiol Gastrointest Liver Physiol. ;
Klement, L., Jansakun, C., Yan, B., Staffer, S., Tuma-Kellner, S., Altamura, S., Muckenthaler, M., Merle, U., Chamulitrat, W. (2024) Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1a activation, Biochim Biophys Acta Mol Basis Dis. ;
Li, H., Seessle, J., Staffer, S., Tuma-Kellner, S., Poschet, G., Herrmann, T., Chamulitrat, W. (2023), FATP4 deletion in liver cells induces elevation of extracellular lipids via metabolic channeling towards triglycerides and lipolysis, Biochem Biophys Res Commun. ;
Göcebe, D., Jansakun, C., Zhang, Y., Staffer, S., Tuma-Kellner, S., Altamura, S., Muckenthaler, M., Merle, U., Herrmann, T., Chamulitrat, W. (2023), Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet, Am J Physiol Gastrointest Liver Physiol. ;
Jansakun, C., Chunglok, W., Altamura, S., Muckenthaler, M., Staffer, S., Tuma-Kellner, S., Merle, U., Chamulitrat, W. (2023), Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH, Biochim Biophys Acta Mol Basis Dis. :
Andrade, A., Poth, T., Brobeil, A., Merle, U., Chamulitrat, W. (2022), iPLA2beta-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment., Int J Mol Sci. ;
Li, H., Herrmann, T., Seeßle, J., Liebisch, G., Merle, U., Wolfgang Stremmel, W., Chamulitrat, W. (2022), Role of fatty acid transport protein 4 in metabolic tissues: insights into obesity and fatty liver disease, Biosci. Rep. ; 42(6)
Wong, H. Y., Langlotz,M., Gan-Schreier, H., Xu, W., Staffer, S., Tuma-Kellner, S., Liebisch, G., Merle, U., Chamulitrat, W. (2021), Constitutive oxidants from hepatocytes of male iPLA2beta-null mice increases the externalization of phosphatidylethanolamine on plasma membrane, Free. Radic. Res.; 55(6)
Zhang, Y., Wu, N., Gan-Schreier, H., Xu, F., Tuma-Kellner, S., Staffer, S., Seeßle. J., Merle, U., Chamulitrat, W. (2021), FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides, Biochem J.; 478(10)
Chamulitrat, W., Jansakun, C., Li, H., Liebisch, G. (2020), Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2beta-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver, Biomolecules; 10(9):1332
Cheng, Y., Gan-Schreier, H., Seeßle, J., Staffer, S., Tuma-Kellner, S., Khnykin, D., Stremmel, W., Merle, U., Herrmann, T., Chamulitrat W. (2020), Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice, Mol. Nutr. Food Res.; 64(22)
Ming, Y., Zhum, X., Tuma-Kellner, S., Ganzha, A., Liebisch, G., Gan-Schreier, H., Chamulitrat, W. (2019): iPla2beta Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation, Cells ; 8(8):879
Otto, A.C., Gan-Schreier, H., Zhu, X., Tuma-Kellner, S., Staffer, S., Ganzha, A., Liebisch, G., Chamulitrat W. (2019): Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling, Biochim. Biophys. Acta Mol. Cell. Biol. Lipids; 1864(5), 662-676
Zhu, X., Gan-Schreier, H., Otto, A.C., Cheng, Y., Staffer, S., Tuma-Kellner, S., Ganzha, A., Liebisch, G., Chamulitrat, W. (2019): iPla2beta deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes, Biochim. Biophys. Acta Mol. Cell Biol. Lipids; 1864 (5), 677-687

Some Older Papers 2

Döring, S., Seesle, J., Gan-Schreier, H., Javaheri, B., Jiao, L., Cheng, Y., Tuma-Keller, S. Liebisch, G., Herrmann, T., Stremmel, W., Chamulitrat, W. (2018): Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets, Mol. Genet. Metab.; 126 (1), 30-38
Horvatova, A., Utaipan, T., Otto, A.C., Gan-Schreier, H., Pavek, P., Pathil, A., Stremmel, W., Chamulitrat, W. (2018): Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages, Eur. J. Pharmacol.; 825, 63-74
Li, J., Gan-Schreier, H., Zhu, X., Wei, W., Tuma-Kellner, S., Liebisch, G., Stremmel, W., Chamulitrat, W. (2017): Ageing sensitized by iPLA2beta deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids, Biochimica et Biophysica Acta (BBA); 12, 1520-1533
Utaipan, T., Otto, A.C., Gan-Schreier, H., Chunglok, W., Pathil, A., Stremmel W, Chamulitrat W. (2017): Ursodeoxycholyl Lysophosphatidylethanolamide Protects Against CD95/FAS-Induced Fulminant Hepatitis, Shock; 48(2), 251-259
Deng, X., Wang, J., Li, J., Utaipan, R., Tuma-Kellner, S., Schmitz, G., Liebisch, G., Stremmel, W., & Chamulitrat, W. (2016): iPLA2beta deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling, {\em Biochimica et Biophysica Acta (BBA); 1861 (5), 449-461
Inhoffen, J., Tuma-Kellner, S., Straub, B., Stremmel, W., & Chamulitrat, W. (2015): Deficiency of iPLA2ß Primes Immune Cells for Proinflammation: Potential Involvement in Age-Related Mesenteric Lymph Node Lymphoma, cancers; 7, 2427-2442
Pathil, A., Liebisch, G., Okun, J.G., Chamulitrat, W., Schmitz, G. & Stremmel, W. (2015): Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD, European Journal of Clinical Investigation
Li, J., Inhoffen, J., Gan-Schreier, H., Tuma-Kellner, S., Stremmel, W., Sun, Z. & Chamulitrat, W. (2015): Deficiency of Group VIA Phospholipase A2 (iPLA2ß) Renders Susceptibility for Chemical-Induced Colitis, Digestive Diseases and Sciences
Li, J., Gan-Schreier, H., Tuma-Kellner, S., Stremmel, W., & Chamulitrat, W. (2015): Sensitization to Autoimmune Hepatitis in Group VIA Calcium-independent Phospholipase A2-null Mice Led to Duodenal Villous Atrophy with Apoptosis, Goblet Cell Hyperplasia and Leaked Bile Acids, Biochimica et Biophysica Acta (BBA)
Wang J., Deng, X., Yi, S, Pathil, A., Zhang, W., Setchell, K., Stremmel, W., & Chamulitrat, W. (2015): Ursodeoxycholyl lysophosphatidylethanolamide protects against hepatic ischemia and reperfusion injury in mice. Shock , 43(4): 379-86.
Seeßle J., Liebisch G., Schmitz G., Stremmel W., & Chamulitrat W. (2015): Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis, Biochim Biophys Acta ; 1851(5): 549-65.
Sellinger, M., Xu, W., Pathil, A., Stremmel, W. & Chamulitrat, W. (2015): Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins. Exp Biol Med (Maywood), 240(2):252-60.
Pathil, A., Mueller, J., Ludwig, JM., Wang J., Warth, A., Chamulitrat, W. & Stremmel, W. (2014): Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-ß1/Smad2/3 signalling. Br J Pharmacol, 171(22):5113-26.
Stremmel, W., Staffer, S., Wannhoff, A., Pathil, A., & Chamulitrat, W. (2014): Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. FASEB J. , 28(7):3159-70.
Chamulitrat, W., Liebisch, G., Xu, W., Gan-Schreier H., Pathil, A., Schmitz, G., & Stremmel, W. (2013): UDCA-LPE Inhibits Lipoapoptosis by Shifting Fatty Acid Pools towards Mono- and Polyunsaturated Fatty Acids in Mouse Hepatocytes
Chamulitrat, W., Zhang, W., Xu, W., Pathil, A., Setchell, K., and Stremmel, W. (2012): Hepaprotectant ursodeoxycholyl lysophosphatidylethanolamide increasing phosphatidylcholine levels as a potential therapy of acute liver injury, Frontiers in Physiology
Sun Q., Sattayakhom A., Backs J., Stremmel W., & Chamulitrat W.: Role of myocyte enhancing factor 2B in epithelial myofibroblast transition of human gingival keratinocytes. Experimental Biology and Medicine , 2012, 178-185. paper
Sattayakhom A., Ittiwat W., Stremmel W., & Chamulitrat W.: Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells. J Cancer Res Clin Oncol., 2011, Aug 30. Paper
Chamulitrat, W.: Role of gp91phox Homolog Nox1 in Induction of Premalignant Spindle Phenotypes of HPV 16 E6/E7–Immortalized Human Keratinocytes; The Scientific World Journal, 10, 1435–1449, 2010; or here: Table of Contents (TOC) (July)
Chamulitrat, W., Burhenne, J., Rehlen, T., Pathil, A., & Stremmel, W.: Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent, Hepatology, 50(1), 143-154, 2009. see also PubMed Entry
Thongphasuk P., Stremmel W., & Chamulitrat W.: ``2,3-Dehydrosilybin Is a Better DNA Topoisomerase I Inhibitor than Its Parental Silybin'', Chemotherapy, 55(1): 42-48, 2009.
Huber, A., Thongphasuk P., Erben, G., Lehmann, W., Tuma, S. Stremmel W, & Chamulitrat W.: ``Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin'', Biochimica et Biophysica Acta, 2008, 1780(5), 837-847 see also PubMed Entry
Thongphasuk P., Stremmel W., & Chamulitrat W.: ``Potent direct or TNF-alpha-promoted anticancer effects of 2,3-dehydrosilybin: comparison study with silybin'', Chemotherapy, 2008; 54(1): 23-30. (PMID: 18063863 )
Chamulitrat, W., Huber, A., Riedel, H.D. & Stremmel, W.: ``Nox1 Induces Differentiation Resistance in Immortalized Human Keratinocytes Generating Cells that Express Simple Epithelial Keratins'', Journal of Investigative Dermatology, vol. 127, 2171-2183 (Sept. 1, 2007)
Chunglok, W., Ittarat, W., Tomakidi, P., Schmidt, R., Stremmel W., & Chamulitrat W.: ``Human gingival mucosal keratinocytes exhibiting anchorage-independent growth express increased inducible nitric oxide synthase: regulation by MAP kinases'', Nitric Oxide: Chemistry and Biology, Nov 2004; 11 (3) 237-246
Our Cells made it to the cover page.
Journal of Investigative Dermatology, April 2004
Oncogene, Sept-04-2003
European Journal of Cell Biology, June 2003
Presentation at BDEG Workshop

PubMed lists a total of 95 papers, not including my papers in Physical Chemistry.

Free Radicals:

Free Radicals in Tissues
Virtual Free Radical School

Some Pictures: Work Related

Professional Activities

My Graduation by King Mahidol of Thailand
My PhD Advisor Larry Kevan in 1986
My Mentor Ron Mason in 1991
Spin trapping 1990
Spin trapping 1991
Gordon Conference 1995
Physiology Dept. at LSU New Orleans with L. Ignarro That was the day Prof. L. Ignarro gave a Nobel prize lecture at the Medical center.
Students in my Lab in New Orleans
Students and Teddy in New Orleans
Gordon Conference 1998
Occ 1998
Nox 2001
Spin trapping 2001
Spin trapping 2001
Spin trapping 2002
Ron Mason's Group 2002
Falk Liver Conference in Hannover, Oct. 2009: 1, 2, 3
Alzbeta and the Group, 2015, in "Studentenkarzer"
Alzbeta, Peter Pavek, and the Group, 2015, in the "Alte Aula"
Ann-Christin received a stipend for her research in April 2016
Ann-Christin in Boston November 2016
Ann-Christin, Chelsea, and Xingya, Heidelberg, May 1, 2017

My Liver Disease and Cancer Group at the University Klinikum

Apsorn and Phanit’s visit to our lab in Sept2017

Visit by Warangkana and Apsorn, July 2015

Tanyarath Graduation in Bangkok

Farewell Party for Apsorn, April 2011

Meeting with my ex-students and friends in Bangkok, March 2019

Some Pictures: Family Related

My Family in Thailand

Two movies with mother playing cards with Yai (you must use media player software):

Mother playing cards with my brother Yai in my mothers house 1 Even the fan turns crazy:-)
Mother playing cards with my brother Yai in my mothers house 2

My Brother's Photo Studio in Njam Wongwan, Bangkok

My Orchids

I have had this hobby of growing orchids since 1990 starting in Raleigh, North Carolina, and then in New Orleans, Louisiana. We have had a good collection of about 50 plants in both homes in NC and LA. When we moved to Heidelberg, Germany, we brought with us about 30 plants after a rather long application and inspection with the US Wildlife office and the US Department of Agriculture.

All of our orchid plants have been doing very well in Heidelberg. We always have some plants in bloom throughout the year. We have Dendrobium hybrids bloom in the summer, and Phalenopsis in bloom during the Winter. We are also able to get some original Thai orchids to bloom as well in Heidelberg - they never did bloom in the US. Here are some examples of our orchids:

Some Orchid Flowers in 2017

Aerides houlletiana	Asc. Udomchai beauty	Asc. Udomchai 'Bart'	Christensonia vietnamica x neof. Falcata	Coelogyne fimbriata
Den. venustrum	Den. capituiliflorum	Den. Draconis	Den. Farmeri	Den. Parishii
Den. Purpureum	Den. Rhodostictum	Den. Sulcatum	Epidendrum Green Hornet x fragrans	Paph. Concolor
Rhetm. Sagarik x Asc. Curvifolium	Rhyncostylis coelistis	Vanda_lamella x Coerula	Vanda Magic Pink

Dendrobium	Dendrobium	Dendrobium	Dendrobium	Dendrobium
Phalenopsis	Phalenopsis	Phalaenopsis	Phalaenopsis	Phalaenopsis
Rhyngigantea	Rhyngigantea	Rhyngigantea	Rhyngigantea	Phalaenopsis
Asconcendra	Asconcendra	Asconcendra	Asconcendra	Phalaenopsis
Brassia	Brassia	Brassia	Our "Ballerina" plant
Vanda	Vanda	Colesteries

Some Orchid Flowers in 2016

Our Redlight Ballett
Blue Vanda 1: Magic Blue	Blue Vanda 2: Magic Blue
White Vanda 1: Lavendel Mist	White Vanda 2: Lavendel Mist

Some Orchid Flowers in 2014

Some Orchid Flowers in 2012

Yellow Dendrobiums	Asconcendras	Dark Purple Vanda
Light Purple Vanda	Thai Chang Dang	Yellow Catteleya

Some Orchid Flowers in 2010

Mini Pink Cattleya	White Cattleya	Pink Cattleya
Phalenopsis	Paphiopedilum concolor (Thailand)	Chostylis (Thailand)
Sri-Siam Rhynochostylis Gigantea 1	Sri-Siam Rhynochostylis Gigantea 2	Yellow Dendrobium 1
Dendrobiums	Yellow Dendrobium 2	Jaquelin Thomas Dendrobium 1
Asconcendra 1	Vanda 1	Vanda 2
Vanda 3	Jaquelin Thomas Dendrobium 2	Neo Falcata (Thailand)

Some Orchid Links

At Christmas of 2002, we purchased this antique Buddha head sculpture from an auction house down the street from our home. This is from the Sukothai era (14th century). A German engineer working for the King of Siam in the early 1900's, was collecting Thai antiques. Coming back to Germany in the 1920's, he brought his antique collection to Heidelberg. Some more Thai art and culture is here.

Two Home Towns: Udon and Bangkok

Born in Bangkok I grew up in Udon Thani where my father had his business. For college I went back to Bangkok.

Wat phrakao at night decorated with lights for the celebration of the King's birthday. This decoration takes place every year. This picture was taken 20 years ago by my brother Yai.

Map of Udon Thani Shrine in Udon Thani Historic Structure in Udon Thani
Bangkok during APEC 2003: 1 Bangkok during APEC 2003: 2 Bangkok during APEC 2003: 3
Bangkok during APEC 2003: 4 Bangkok during APEC 2003: 5
Bangkok during APEC 2003: 6 Bangkok during APEC 2003: 7 (Fireworks) Bangkok during APEC 2003: 8 (Fireworks)
Bangkok during APEC 2003: 9 Bangkok during APEC 2003: 10 Bangkok during APEC 2003: 11
Bangkok during APEC 2003: 12 Bangkok during APEC 2003: 13 Bangkok during APEC 2003: 14

Some Links:

NC and Private Traveling

In Heidelberg

Contact information:

Dept. of Internal Medicine IV, Forschungsgruppen, University of Heidelberg, Im Neuenheimer Feld 345, D 69120 Heidelberg
email (please note the underscore): walee_chamulitrat@med.uni-Heidelberg.de

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